貨號 | 品牌 | CAS | 規(guī)格 | 銷售價(RMB) | 折扣價(RMB) | 備注 | 數(shù)量 |
ABP0077-100μL | Abbkine | 無 | 100μL | 1998 | 1998 | 無 |
產(chǎn)品英文名稱 | Cyclin D1 Polyclonal Antibody |
免疫原 | 合成多肽:人源Cyclin D1 非磷酸化位點為中心:T286 |
宿主 | 兔 |
反應性 | 人, 大鼠, 小鼠 |
應用 | ELISA, IF, IHC-P, WB |
實驗建議 | 最佳的工作稀釋比例需要客戶摸索優(yōu)化。建議的起始嘗試的稀釋比為:WB:1:500-1:2000,IF:1:50-1:200,IHC-P:1:100-1:300,ELISA:1:40000。 |
克隆性 | 多克隆 |
純化工藝 | 使用表位特異性的免疫原,通過親和層析,從兔抗血清中親和純化抗體。 |
產(chǎn)品形式 | 液體溶液 |
濃度 | 1 mg/ml |
分子量 | 33 KD |
儲存緩沖液 | PBS緩沖液(pH 7.4),含有0.5%BSA(穩(wěn)定劑),0.02%疊氮化鈉(防腐劑)和50%甘油。 |
保存建議 | 自發(fā)貨之日起,-20°C可穩(wěn)定保存1年。為最大限度的避免損失,請在打開管蓋之前融化抗體并離心。我們建議使用前分裝以避免反復凍融。 |
運輸條件 | 藍冰運輸 |
警告 | 本文列出的產(chǎn)品僅供研究使用,不適用于人類或臨床診斷。我們產(chǎn)品所推薦應用,不是建議使用我們的產(chǎn)品去違反任何專利或許可證。對于使用本產(chǎn)品可能發(fā)生的專利侵權或其他違規(guī)行為,我們不承擔任何責任。 |
背景 | Cyclin D1 encoded by CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. Cyclin D1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of CCND1, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. |
基因ID | 595 |
別名 | CCND1; BCL1; PRAD1; G1/S-specific cyclin-D1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene |
其它 | 該抗體可檢測內(nèi)源蛋白 |
蛋白質(zhì)ID | P24385 |
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